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It acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, enzymes that are critical for one-carbon metabolism as well as the catabolism of odd-chain fatty acids and branched-chain amino acids (Rucker et al., 2007)

The type of B12 supplement might matter too

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Individuals with methylation issues, such as those with MTHFR variants, might respond differently to NNMT inhibition

If you have been on long term medication like omeprazole or lansoprazole, have had a poor diet or are vegan/vegetarian you may benefit from having a course of Vitamin B12 Injections